Dr. José M. Sánchez-Ruiz
Departamento de Química Física, Universidad de Granada
Using ancestral resurrection to probe evolutionary protein
Degree in Chemistry. University of Granada (Spain). 1979. Ph.D. in Physical Chemistry. University of Granada, 1983. Fulbright Scholar: 1984-1986. The Medical College of Virginia (USA). Current position: Professor of Physical Chemistry, University of Granada. Member of the Editorial Board of Biophysical Chemistry (2004-2010). Member of the Editorial Board of Biochemical Journal (2008- in active). Academic Editor of PLOS ONE (2012- in active).
Relation structure-energetics in proteins. Protein folding. Solvent effects on protein stability. Electrostatic contributions to protein stability. Rational design of thermostable proteins. Residual structure in denatured states. Protein evolution. Protein design.
Industrial experience: Collaboration agreements with Novozymes and Noricum (a Spanish company devoted to the development of applications of bone morphogenetic proteins).
-13 invited talks in scientific meetings in the period 2010-2014).
Selected publications from the last five years:
-Risso et al. (2014). Molecular Biology and Evolution, doi: 10.1093/molbev/msu310.
-Zou et al. (2014) Molecular Biology and Evolution, doi: 10.1093/molbev/msu281.
-Ingles-Prieto et al. (2013). Structure 21, 1690-1697.
-Risso et al. (2013). Journal of the American Chemical Society 135, 2899-2902.
-Kosuri et al. (2012). Cell 151, 794-806.
-Garcia-Seisdedos et al. (2012). PLoS Computational Biology 8(6):e1002558.
-Perez-Jimenez et al. (2011). Nature Structural and Molecular Biology 18, 592-596.
-Sanchez-Ruiz (2011) Annual Review of Physical Chemistry 62, 231-255.
-Naganathan et al. (2010). Journal of the American Chemical Society 132, 11183-11190.
-Sanchez-Ruiz (2010). Protein kinetic stability. Biophysical Chemistry 148, 1-15.
-Pey, D. et al. (2010). Modulation of buried ionizable groups in proteins with engineered surface charge. Journal of the American Chemical Society 130, 7489-7495.