Dr. Juan S. Jiménez
Universidad Autónoma de Madrid. Applied Physical Chemistry Department
A surface plasmon resonance study of the DNA interaction with Tau protein and amyloid peptides, involved in the molecular basis of Alzheimer´s disease.
Juan S. Jiménez graduated from Murcia University. He received his PhD at the Granada University. Along 1978 and 1979 he joined the group of Prof. Shmuel Shaltiel as a postdoctoral fellow at the Weizmann Institute of Science, Israel. In 1982 he moved to Autonomous University of Madrid. At present he is a Physical Chemistry Professor at the Applied Physical Chemistry Department of this University.
Research in the Prof Jiménez’s laboratory has been focused on the structure-function relationship of enzymes and proteins. Over the last ten years they have been particularly interested in the molecular basis of Alzheimer’s Disease. This severe disorder is characterized by the presence in the brain of two types of aberrant structures: intraneuronal neurofibrillary tangles and extracellular senile plaques. The former are composed mainly of tau protein, while the main component of senile plaques is amyloid peptide, Aβ. The Prof Jiménez’s group has developed a Surface Plasmon Resonance set-up which allows the study of DNA-peptide/protein interactions. Results obtained by means of this technique have led them to pose the hypothesis that an alteration of transcription provoked by an interaction of amyloid peptides with nucleic acids, in which tau protein is somehow implicated, may represent an important contribution to the origin of Alzheimer’s Disease.