Dr. Juan R. Granja
Department of Organic Chemistry and Center for Research in Biological Chemistry and Molecular Materials (CIQUS)
Membrane targeting self-assembling peptides
Prof. Juan R. Granja received the PhD in chemistry from the University of Santiago de Compostela in 1988, under the guidance of Profs. Antonio Mouriño and Luis Castedo, working on the synthesis of main metabolites of vitamin D2. After twenty one months of postdoctoral studies in the group of Prof. Barry M. Trost at the Chemistry Department of Stanford University working on the synthesis of macrolides using Pd chemistry, he returned to the University of Santiago as Assistant Professor (Oct-1991). In 1992 he spent six months in the group of, at that time, Assistant Professor M. Reza Ghadiri at The Scripps Research Institute in La Jolla, starting a long and productive scientific collaboration, including several visits at The Scripps. As a consequence of this scientific collaboration, novel studies on peptide chemistry were developed, such as self-assembling peptides, peptide nanotubes, supramolecular antimicrobial agents or self-replicating processes. In 1995 he was promoted at the University of Santiago de Compostela to Associate Professor and in 2006 to Full Professor after a national habilitation in 2005. His research interest is devoted to the synthesis of complex structures by efficient methods. One of these programs is seeking for the synthesis of functional nanotubes by self-assembling process of cyclic peptides. Specially, he is interested on peptide nanotubes based on cyclic peptides that contain cyclic gamma-amino acids. These supramolecular entities are designed to achieve efficient transmembrane transport.