Dr. Irene Luque
Department of Physical Chemistry and Institute of Biotechnology. University of Granada, Granada, Spain
Structural and thermodynamic studies of viral Late domain interactions: towards the development of host-oriented therapeutics.
Irene Luque Fernández obtained her PhD at the University of Granada in 1998. She worked at the Department of Biology and Biocalorimetry Center at The Johns Hopkins University from 1998-2001 on the development of structural-thermodynamic parameterizations for the prediction of binding energetics and its application to the study of molecular basis of protein cooperativity and resistance to HIV-1 protease inhibition. In 2002 she enrolled back to the University of Granada as a Ramón y Cajal Researcher. Currently, she is Professor of Physical Chemistry and research fellow at the Institute of Biotechnology in the University of Granada. Her work is devoted to the structural and thermodynamic analysis of the molecular determinants of proline-rich sequence recognition by protein-protein interaction domains. Specifically, during the last years her research has been focused on the identification and development of inhibitors of viral Late domain interactions with their cellular partners (Tsg101-UEV and Nedd4-WW3 domains) with potential as wide-spectrum host oriented therapeutic agents.