Dr. Jerónimo Bravo
Instituto de Biomedicina de Valencia, Department of Genomics and Proteomics
Role of the carboxy-terminal domain of Erb1 during ribosome biogenesis in the formation of the Nop7/PeBoW complex.
Jerónimo Bravo graduated at the Universidad Autónoma de Barcelona, Spain. He obtained an MSc degree from the same University focusing on the search for tumour markers in pancreatic cancer. He then joined I. Fita’s group in 1991 at the Universitat Politècnica de Catalunya, Barcelona. His thesis involved the study of the mechanism of Reactive Oxygen Species detoxification - the 3D structure of catalases in particular.
In 1996 he obtained a postdoctoral fellowship from the Spanish Ministry of Science and Education followed by a European Community research grant to join Y. Jones at the Laboratory of Molecular Biophysics, University of Oxford, UK where he solved the structure of the cytokine-binding homology region of gp130, which is required for signal transduction by a set of cytokines (leukaemia inhibitory factor or oncostatin).
In 1998 Dr. Bravo switched from Oxford to Cambridge to join R. Williams at the Molecular Biology Laboratory. Jerónimo was the first to report a structure of a PX domain in complex with a phosphoinositide, providing key evidence for the lipid specificity and membrane targeting mechanism of PX domains. Work on transcription factors in collaboration with T. H. Rabbitts also contributed to the understanding of the molecular aspects of genetic abnormalities present in acute leukaemia.
Returning home to Spain in April 2002 he was appointed as Group Leader of the CNIO Signal Transduction Group were he focused on the molecular mechanisms of tyrosine kinase receptors downregulation and metastasis. In 2009 he obtained a position at the Instituto de Biomedicina de Valencia (CSIC) were he was appointed head of department and later deputy director until 2015 focusing on the structure and function of abnormal cell proliferation and control of gene expression.