Dr. Mario Mellado
Dpt. Immunology & Oncology, CNB/CSIC
Studying chemokine receptor conformations and dynamics at the cell membrane.
Dr. Mario Mellado (University of Alcalá, 1990) initiated his scientific career in 1991 at Pharmacia Iberia, SL. In 1993, he joined the Department of Immunology and Oncology (DIO) at the National Center for Biotechnology/CSIC and initiated his independent research group studying the chemokine/chemokine receptor biology. He described for the first time that the chemokines activate the JANUS kinase family and that the chemokine receptors form homo and heterodimers at the cell surface. In this period stand out more than 50 publications, 4 patents and he supervised 4 PhD theses. In 2005, he obtained a permanent position at the CSIC and he incorporated to the chemokine receptor analysis, new image techniques based on resonance energy transfer (FRET and BRET). He thus confirmed the existence of dynamic chemokine receptor complexes. At this second stage he supervised 7 PhD theses, published 50 manuscripts in international peer-review journals and wrote 1 patent. He then became interested in more translational aspects of his research allowing him to be part of two European consortia funded in the context the 7th framework program and two national consortia for studying rheumatic diseases that brings him closer to clinical research.
He is now interested in TIRF-M technology (total internal reflection microscopy) as allows him to analyze the dynamics of chemokine receptors at the cell membrane and to define new therapeutic tools based on chemokine receptor oligomerization.