XV congreso de la SBE: Granada 2015
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Satellite Workshop: "New & Notable in Biophysics"

Dr. Borja Ibarra

IMDEA Nanociencia

Understanding how biological molecular motors work: identification of the translocation step of a replicative DNA polymerase.

Borja Ibarra received his Ph.D. in Molecular Biology from Universidad Autónoma Madrid. He made the ‘leap’ to molecular biophysics as a postdoctoral fellow at University of California, Berkeley, where he used optical tweezers to study at single-molecule level the dynamics of molecular motors involved in DNA replication. Back in Spain, he applied the optical tweezers technology at IMDEA Nanoscience to study the physical-chemical and mechanistic principles that govern the operation of biological molecular motors at the nanoscale.

Recent Publications

  • J.A. Morin, F.J. Cao, J.M. Lázaro, J.R. Arias-Gonzalez, J.M. Valpuesta, J.L. Carrascosa, M. Salas, B. Ibarra (2015). Mechano-chemical kinetics of DNA replication: identification of the translocation step of a replicative DNA polymerase. Nucleic Acid Research DOI: 10.1093/nar/gkv204
  • J.A. Morin, F.J. Cao, J.M. Lázaro, J.R. Arias-Gonzalez, J.M. Valpuesta, J.L. Carrascosa, M. Salas, B. Ibarra (2012). Active DNA unwinding dynamics during processive DNA replication. PNAS, USA 109(21): 8115-20.
  • Morin J.A., Cao F.J., Valpuesta J.M., Carrascosa J.L., Salas M., Ibarra B. (2012). Manipulation of single polymerase-DNA complexes: A mechanical view of DNA unwinding during Cell Cycle 11(16): 2967- 2968.
  • Ibarra B., et al. (2009). Proofreading Dynamics of a Processive DNA Polymerase. EMBO J., 28: 2794 – 2802.